Why the study?
Does aging alter cardiac NOS activity and expression in genetically heart failure-prone rats compared to hypertensive and normal rats?
Population
Genetically heart failure-prone rats, spontaneously hypertensive rats, and Sprague-Dawley rats at 6, 12, and…
Comparison
Aging (evaluated at 6, 12, and 18 months of age) vs Age-matched spontaneously hypertensive and…
Design
Preclinical
Follow-up
Up to 18 months of age
Authors
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May indicate compensatory eNOS upregulation in genetic HF; hypothesis-generating for human translation and requires validation beyond rodents.
Does aging alter cardiac NOS activity and expression in genetically heart failure-prone rats compared to hypertensive and normal rats?
Genetically heart failure-prone rats exhibit a unique age-dependent augmentation of cardiac endothelial NOS activity and expression compared to hypertensive and normal controls.
Khadour et al. (1997) studied this question.
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