Key result
Spontaneously hypertensive rats developed endothelial dysfunction by 20 weeks of age and exhibited reduced NOS activity at 52 weeks compared to normotensive Wistar-Kyoto rats.
Why the study?
The study examined the role of the NOS/NO/sGC signaling pathway in vasoactive control of the thoracic aorta across early to late ontogenetic stages in normotensive versus spontaneously hypertensive rats.
Population
Normotensive Wistar-Kyoto and spontaneously hypertensive rats at 7, 20, and 52 weeks old
Comparison
SHRs vs age-matched WKYs across 7, 20, and 52 weeks of age
Design
Preclinical animal study
Authors
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No practice change from rat data; leaves open NOS modulation as a human hypertension target.
In contrast to spontaneously hypertensive rats, normotensive rats appear able to maintain endothelial function and optimal blood pressure during aging by increasing NOS activity.
Berenyiová et al. (2022) studied Hypertension. Spontaneous hypertension (SHR strain) vs. Normotensive Wistar-Kyoto (WKY) rats was evaluated on Vasoactive control of the thoracic aorta (endothelium-dependent relaxation and NOS activity). Spontaneously hypertensive rats developed endothelial dysfunction by 20 weeks of age and exhibited reduced NOS activity at 52 weeks compared to normotensive Wistar-Kyoto rats.
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