What does this research mean for the field?

During early life aging (juvenescence to young adulthood), vascular nitric oxide production and bioavailability decrease in both normotensive and hypertensive rats, but this reduction is fully compensated by an increase in NO-independent vasorelaxation mechanisms. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2014BioMed Research InternationalOpen Access

Age-Related Alterations in Endothelial Function of Femoral Artery in Young SHR and WKY Rats

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Population

Juvenile and young adult male Wistar-Kyoto and spontaneously hypertensive rats, n=8-10 per group.

Comparison

Aging and genetic hypertension model vs Juvenile rats and normotensive WKY rats

Design

Preclinical

Authors

APAngelika PúzserováSlovak Academy of Sciences VIVeronika IlovskaSlovak Academy of Sciences PBPeter BališSlovak Academy of Sciences

Discussion

Member takes

Implication

Does not support clinical changes in vascular aging management; leaves open human relevance of NO-independent compensation.

Structured PICO

Population

Juvenile (7-week-old) and young adult (22-week-old) male Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR), n=8-10 per group.

Intervention

Aging (from 7 to 22 weeks of age) and genetic hypertension model (SHR)

Comparator

Juvenile rats (for aging comparison) and normotensive WKY rats (for hypertension comparison)

Outcome

Endothelial function assessed by NO-mediated relaxations in femoral arteries and NO synthase activity in aortasurrogate

In early life, age-related reductions in vascular NO bioavailability occur in both normotensive and hypertensive rats but are compensated by NO-independent mechanisms to maintain endothelial function.

Limitations

NOS activity was measured in the aorta rather than the femoral artery due to insufficient tissue
Activity of individual NOS isoforms (eNOS, iNOS) was not measured

Cite This Study

Púzserová et al. (2014) studied this question.

synapsesocial.com/papers/6a19c11b407564563bf67f57 https://doi.org/10.1155/2014/658479

Topics

Hypertension management

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