The study demonstrates that the majority of Lansing poliomyelitis virus in infected cotton rat CNS tissue is located in the submicroscopic particle fraction.
No direct clinical implications for poliomyelitis; leaves open further characterization of viral localization in animal CNS models.
A procedure has been described for the centrifugal fractionation of the cellular particulate components of CNS tissue infected with poliomyelitis virus. A study of the distribution of infectivity among these components revealed that approximately four-fifths of the virus is found free in the submicroscopic particle fraction. The validity of the conclusion that the virus is located in this fraction of the intact neuron is discussed.
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Schwerdt et al. (1952) studied this question.
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