Why the study?
ACIP recommends avoiding live viral vaccines during the first year of life in infants exposed to biologic response modifiers during pregnancy, but information regarding adverse events after inadvertent administration is limited.
Is rotavirus immunization safe in infants born to mothers treated with immunosuppressive drugs for inflammatory bowel disease during pregnancy?
Is rotavirus immunization safe in infants born to mothers treated with immunosuppressive drugs for inflammatory bowel disease during pregnancy?
Live viral vaccines like the rotavirus vaccine may be safe in infants exposed to biologic response modifiers in utero, which could affect current ACIP recommendations to avoid them.
The licensed rotavirus vaccines are live attenuated and are a component of the routine U.S. childhood immunization schedule. Live vaccines administered to infants of mothers who received biologic response modifiers (BRM) during pregnancy can potentially cause serious vaccine-associated disease. The Advisory Committee on Immunization Practices (ACIP) recommends infants born to women who received BRM during pregnancy avoid live viral vaccines during the first year of life. There is a paucity of information regarding adverse events following inadvertent administration of live viral vaccines in these infants. We report three infants, born to mothers receiving infliximab during pregnancy, who tolerated multiple doses of rotavirus vaccine. Live viral vaccines may be safe in infants who were exposed to BRM in utero. Further studies are needed to support this observation, as this could affect current ACIP recommendations.
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Smith et al. (2020) studied this question.
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