Population
Murine norovirus models
Comparison
Primary infection with murine norovirus strains vs Comparison between MNV-1 and MNV-3 strains
Design
Preclinical
Authors
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Strain-specific MNV protection in mice cautions against extrapolation; leaves open optimal strain selection for human norovirus vaccines.
Highly genetically related intra-cluster murine norovirus strains differ dramatically in their ability to induce a protective immune response, highlighting the importance of considering virus strain-specific effects in vaccine development.
Zhu et al. (2013) studied this question.
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