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January 1, 1997Hypertension

Selective Guanylyl Cyclase Inhibitor Reverses Nitric Oxide-Induced Vasorelaxation

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Population

COS-7 cells overexpressing alpha 1 and beta 1 subunits of rat soluble guanylyl cyclase, rat aortic vascular…

Comparison

ODQ 10 mumol/L vs Absence of ODQ

Design

Preclinical

Authors

LOLinda J. OlsonMedical College of WisconsinEKEdward T. KnychUniversity of Minnesota, DuluthTHThomas C. HerzigNaval Health Research Center

Discussion

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Implication

Supports sGC as NO mediator in aortas; leaves open translation to hypertension therapies.

Structured PICO

P
Population
COS-7 cells overexpressing alpha 1 and beta 1 subunits of rat soluble guanylyl cyclase, rat aortic vascular smooth muscle cells, and isolated rat aortas
I
Intervention
ODQ (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one) 10 mumol/L
C
Comparator
Absence of ODQ
O
Outcome
Guanylyl cyclase activity (cGMP production) and vasorelaxation of phenylephrine-precontracted aortassurrogate

ODQ selectively inhibits soluble guanylyl cyclase and attenuates NO-mediated vasorelaxation, confirming that soluble guanylyl cyclase mediates the vasorelaxant activity of nitric oxide.

Cite This Study

Olson et al. (1997) studied this question.

synapsesocial.com/papers/6a700a23e5469ee92be0d066https://doi.org/10.1161/01.hyp.29.1.254
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dephosphorylation of the guanylyl cyclase-A receptor causes desensitization.1992 · 231 citations
  2. 2Hyperpolarizing Vasodilators Activate ATP-sensitive K + Channels in Arterial Smooth Muscle1989 · 1,197 citations
  3. 3Natriuretic Peptide Receptor-B (Guanylyl Cyclase-B) Mediates C-type Natriuretic Peptide Relaxation of Precontracted Rat Aorta1995 · 108 citations
  4. 4Seminal plasma factors that cause large elevations in cellular cyclic GMP are C-type natriuretic peptides.1993 · 112 citations
  5. 5The Family of Guanylyl Cyclase Receptors and Their Ligands1994 · 340 citations