Key result
Administration of ODQ (5 mg/kg iv) attenuated vasodilator responses to NO donors but did not inhibit responses to acetylcholine and bradykinin in the systemic and pulmonary vascular beds of the rat.
Population
Rat model (pulmonary and systemic vascular beds)
Design
Preclinical
Authors
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Acetylcholine vasodilation proceeds independently of sGC in rat pulmonary and systemic beds; leaves open alternative pathways and human translation.
In rats, decreases in pulmonary and systemic arterial pressures in response to acetylcholine are not mediated by the activation of soluble guanylate cyclase or TRPV4 channels.
Pankey et al. (2014) studied this question. ODQ (1H-[1,2,4]-oxadizaolo[4,3-]quinoxaline-1-one) was evaluated on Vasodilator responses to acetylcholine and bradykinin. Administration of ODQ (5 mg/kg iv) attenuated vasodilator responses to NO donors but did not inhibit responses to acetylcholine and bradykinin in the systemic and pulmonary vascular beds of the rat.
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