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July 7, 2022BMC Cardiovascular DisordersOpen Access

Validation and derivation of short-term prognostic risk score in acute decompensated heart failure in China

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Why the study?

Few prognostic risk scores have been routinely used in acute decompensated heart failure, motivating the external validation of three published scores and the derivation of a new score.

Does a newly derived prognostic risk score improve the prediction of short-term outcomes in patients with acute decompensated heart failure compared to existing scores?

Population

4550 patients with ADHF from the Heb-ADHF registry in China

Comparison

New prognostic risk score vs 3A3B, AHEAD, and OPTIME-CHF scores

Design

Registry-based derivation and validation cohort study

Authors

HZHong-Liang ZhaoXGXiaoli GaoYLYing-Hua Liu

Discussion

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Overview

New PRS may improve short-term ADHF risk stratification over existing scores; leaves open clinical utility pending prospective validation.

Structured PICO

Does a newly derived prognostic risk score improve the prediction of short-term outcomes in patients with acute decompensated heart failure compared to existing scores?

P
Population
4550 patients with acute decompensated heart failure (ADHF) from the Heb-ADHF registry in China
I
Intervention
Derivation and validation of a new prognostic risk score (PRS) incorporating diastolic blood pressure, lymphocytes, creatinine, BUN, BNP/NT-proBNP, QRS fraction, ACEI/ARB use, and rhBNP use
C
Comparator
Existing prognostic risk scores (3A3B, AHEAD, and OPTIME-CHF)
O
Outcome
Short-term prognosis (predictive ability assessed by AUROC)

A newly derived prognostic risk score incorporating QRS fraction and other clinical variables showed better short-term predictive ability for acute decompensated heart failure than existing scores.

Cite This Study

Zhao et al. (2022) studied this question.

synapsesocial.com/papers/6a700a582fdcb5703edb5302https://doi.org/10.1186/s12872-022-02743-1
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