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September 1, 1986Journal of Clinical MicrobiologyOpen Access

Enzyme-linked immunosorbent assays for Snow Mountain and Norwalk agents of viral gastroenteritis

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Why the study?

Are ELISAs as sensitive and specific as radioimmunoassays for detecting Snow Mountain and Norwalk agents of viral gastroenteritis?

Population

Samples containing Snow Mountain and Norwalk agents of viral gastroenteritis

Comparison

Enzyme-linked immunosorbent assays for antigen… vs Existing radioimmunoassays and blocking…

Design

Other

Authors

HMH P MadoreHuman Immunome ProjectJTJohn J. TreanorCincinnati Children's Hospital Medical CenterKPKatherine PrayUniversity of Massachusetts Chan Medical School

Discussion

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Implication

ELISAs match RIA performance for Snow Mountain/Norwalk detection; leaves open routine clinical adoption without further validation.

Structured PICO

Are ELISAs as sensitive and specific as radioimmunoassays for detecting Snow Mountain and Norwalk agents of viral gastroenteritis?

P
Population
Samples containing Snow Mountain and Norwalk agents of viral gastroenteritis
I
Intervention
Enzyme-linked immunosorbent assays (ELISAs) for antigen detection and blocking ELISAs for serum antibody rises
C
Comparator
Existing radioimmunoassays and blocking radioimmunoassays
O
Outcome
Sensitivity and specificity of the ELISAs compared to radioimmunoassayssurrogate

ELISAs provide a sensitive and specific alternative to radioimmunoassays for detecting Snow Mountain and Norwalk viral gastroenteritis agents.

Cite This Study

Madore et al. (1986) studied this question.

synapsesocial.com/papers/6a700ad178a11c550e09d5e8https://doi.org/10.1128/jcm.24.3.456-459.1986
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Radioimmunoassay for detection of the snow mountain agent of viral gastroenteritis1986 · 36 citations
  2. 2Enzyme-linked immunosorbent assays based on polyclonal and monoclonal antibodies for rotavirus detection1984 · 130 citations
  3. 3Characterization of the Snow Mountain agent of viral gastroenteritis1986 · 45 citations
  4. 4Detection of Norwalk virus in stools by enzyme immunoassay1985 · 72 citations
  5. 5Biological Properties of Norwalk Agent of Acute Infectious Nonbacterial Gastroenteritis1972 · 281 citations