What question did this study set out to answer?

To evaluate aortic compliance and plasma lipoprotein concentrations in young patients with heterozygous familial hypercholesterolaemia compared to healthy matched controls.

December 1, 1992Clinical Science

Aortic compliance in young patients with heterozygous familial hypercholesterolaemia

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Authors

ELEldon D. LehmannMedizinische Hochschule Hannover GWGerald F. WattsUniversity of Notre Dame BFB. Fatemi-LangroudiUniversity of London

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Implication

Matched case-control study demonstrates increased aortic compliance in young patients with familial hypercholesterolaemia, indicating its potential as a non-invasive marker for atheroma risk.

Key Points

To evaluate aortic compliance and plasma lipoprotein concentrations in young patients with heterozygous familial hypercholesterolaemia compared to healthy matched controls.
Measured aortic compliance alongside plasma lipid and lipoprotein profiles in 20 young patients with heterozygous familial hypercholesterolaemia and 20 age- and sex-matched control subjects.
Adjusted compliance for age and sex, and performed univariate correlation and multivariate regression analyses to identify clinical predictors of arterial distensibility.
Patients with familial hypercholesterolaemia had significantly higher plasma cholesterol (P < 0.001), LDL-cholesterol (P < 0.001), triacylglycerol levels (P < 0.005), and significantly more compliant aortas (P < 0.001) than controls.
Normalized aortic compliance correlated positively with total cholesterol (r = 0.50, P < 0.03), LDL-cholesterol (r = 0.54, P < 0.01), LDL/HDL-cholesterol ratio (r = 0.60, P < 0.0006), and disease duration (r = 0.67, P < 0.002), while correlating inversely with HDL-cholesterol (r = -0.44, P < 0.05).
Multivariate regression identified the LDL/HDL-cholesterol ratio (P < 0.03) and duration of disease (P < 0.04) as the strongest independent predictors of normalized compliance.

Cite This Study

Lehmann et al. (1992) studied this question.

synapsesocial.com/papers/6a700ae72163a0a01bc442bf https://doi.org/10.1042/cs0830717

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Implication

Matched case-control study demonstrates increased aortic compliance in young patients with familial hypercholesterolaemia, indicating its potential as a non-invasive marker for atheroma risk.

Aortic compliance in young patients with heterozygous familial hypercholesterolaemia

Discussion

Member takes

Implication

Key Points

Cite This Study

Aortic compliance in young patients with heterozygous familial hypercholesterolaemia

Discussion

Member takes

Implication

Key Points

Cite This Study

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