Key result
Heterozygous familial hypercholesterolaemia is linked to abnormal ankle-arm ratios in ~65% of patients.
Why the study?
Peripheral atherosclerosis is considered infrequent in heterozygous familial hypercholesterolaemia, but its prevalence and characteristics were unclear.
Is peripheral atherosclerosis more common in asymptomatic patients with familial hypercholesterolaemia compared to normolipidaemic controls?
Population
20 asymptomatic familial hypercholesterolaemic patients and age- and sex-matched normolipidaemic controls
Comparison
Familial hypercholesterolaemia vs normolipidaemic controls
Design
Case-control study with non-invasive ankle-arm systolic blood pressure ratio measurement
Authors
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May indicate higher peripheral atherosclerosis burden in asymptomatic FH; hypothesis-generating and requires prospective confirmation.
Case-Control
Is peripheral atherosclerosis more common in asymptomatic patients with familial hypercholesterolaemia compared to normolipidaemic controls?
Absolute Event Rate: 65% vs 5%
Peripheral atherosclerosis is highly prevalent in asymptomatic patients with familial hypercholesterolaemia, suggesting it is a multilevel disease.
Perhoniemi et al. (1989) conducted a case-control in Familial hypercholesterolaemia. Familial hypercholesterolaemia vs. Normolipidaemic controls was evaluated on Abnormal (less than 0.97) ankle-arm systolic blood pressure ratio at rest. Familial hypercholesterolaemia was associated with frequent peripheral atherosclerosis, with an abnormal ankle-arm pressure ratio found in 65% of patients compared to only one control.
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