Key result
Presence of coronary heart disease in patients with heterozygous familial hypercholesterolaemia was associated with significantly higher age-adjusted mean concentrations of fibrinogen and factor VIII.
Why the study?
Are haemostatic variables associated with coronary heart disease in patients with heterozygous familial hypercholesterolaemia?
Population
61 patients with heterozygous familial hypercholesterolaemia, including 32 with evidence of coronary heart…
Design
Cross-sectional
Authors
Loading...
Suggests hypercoagulability may contribute to CHD in HeFH; hypothesis-generating and requires prospective validation before clinical adoption.
Observational (n=61)
Are haemostatic variables associated with coronary heart disease in patients with heterozygous familial hypercholesterolaemia?
Hypercoagulability, indicated by elevated fibrinogen and factor VIII, may contribute to the pathogenesis of coronary heart disease in patients with familial hypercholesterolaemia independently of lipid levels.
Sugrue et al. (1985) conducted an observational in Heterozygous familial hypercholesterolaemia (n=61). Coronary heart disease vs. No coronary heart disease was evaluated on Plasma fibrinogen and factor VIII concentrations. Presence of coronary heart disease in patients with heterozygous familial hypercholesterolaemia was associated with significantly higher age-adjusted mean concentrations of fibrinogen and factor VIII.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: