July 4, 2008AJP Heart and Circulatory Physiology
QT interval variability and cardiac norepinephrine spillover in patients with depression and panic disorder
Why the study?
Does SSRI treatment affect QT variability, and does QT variability correlate with cardiac norepinephrine spillover in patients with depression and panic disorder?
Population
17 subjects (12 with major depressive disorder and 5 with panic disorder)
Comparison
Selective serotonin reuptake inhibitor… vs Baseline (before treatment)
Design
Cohort
Follow-up
4 months
Authors
Discussion
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Member takes
Implication
QT variability was unlinked to norepinephrine spillover and unaffected by SSRI; leaves open its prognostic utility in depression or panic disorder.
Structured PICO
Does SSRI treatment affect QT variability, and does QT variability correlate with cardiac norepinephrine spillover in patients with depression and panic disorder?
P
Population
17 subjects (12 with major depressive disorder and 5 with panic disorder)
I
Intervention
Selective serotonin reuptake inhibitor (SSRI) antidepressants for 4 months
C
Comparator
Baseline (before treatment)
O
Outcome
Relationship between QT variability and cardiac norepinephrine spilloversurrogate
QT variability does not appear to reflect cardiac norepinephrine spillover in patients with depression or panic disorder with near-normal norepinephrine levels, and is unaffected by SSRI therapy.
Cite This Study
Baumert et al. (2008) studied this question.