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March 8, 2012Vascular Medicine

The within-day variability was lower for FMD measurements than for PAT measurements (10% versus 18%; p < 0.05), with a significant correlation between the two methods (r = 0.57, p < 0.001).

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Why the study?

Does flow-mediated dilatation (FMD) provide better reliability and reproducibility than peripheral arterial tonometry (PAT) for assessing endothelial function in patients with coronary heart disease?

Population

18 volunteers with coronary heart disease

Comparison

Flow-mediated dilatation by means of brachial… vs Peripheral arterial tonometry with the EndoPAT…

Design

Cross-sectional

Follow-up

2 days

Authors

SOSteven OnkelinxVCVéronique CornelissenKGKaatje Goetschalckx

Discussion

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Overview

FMD may be preferred for endothelial function testing in coronary heart disease; leaves open outcome prediction or therapy guidance.

Structured PICO

Does flow-mediated dilatation (FMD) provide better reliability and reproducibility than peripheral arterial tonometry (PAT) for assessing endothelial function in patients with coronary heart disease?

P
Population
18 volunteers with coronary heart disease
I
Intervention
Flow-mediated dilatation (FMD) by means of brachial artery ultrasound scanning
C
Comparator
Peripheral arterial tonometry (PAT) with the EndoPAT 2000
O
Outcome
Reliability and reproducibility (within-day and between-day variability)surrogate

FMD demonstrates better within-day reliability and lower typical errors of measurement compared to PAT for assessing endothelial function in patients with coronary heart disease.

Cite This Study

Onkelinx et al. (2012) studied this question.

synapsesocial.com/papers/6a700c5253da1ffdb5079b15https://doi.org/10.1177/1358863x12436708
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reproducibility of brachial ultrasonography and flow‐mediated dilatation (FMD) for assessing endothelial function1997 · 73 citations
  2. 2Reproducibility of peripheral arterial tonometry for the assessment of endothelial function in adults2013 · 63 citations
  3. 3Endothelial function assessment in atherosclerosis. Comparison of brachial artery flow‑mediated vasodilation and peripheral arterial tonometry2013 · 81 citations
  4. 4Variability of Peripheral Arterial Tonometry in the Measurement of Endothelial Function in Healthy Men2009 · 57 citations
  5. 5Test–retest reliability of pulse amplitude tonometry measures of vascular endothelial function: Implications for clinical trial design2012 · 122 citations