September 7, 2010Cancer ResearchOpen Access

Angiopoietin-4 Promotes Glioblastoma Progression by Enhancing Tumor Cell Viability and Angiogenesis

View Full Paper

Ask AI

Bookmark

Population

Human glioblastoma multiforme (GBM) tissues and cells, and in vivo models of human GBM cells

Design

Preclinical

Authors

Discussion

Ang-4-Tie-2 axis merits further preclinical testing in GBM; hypothesis-generating from animal data and not ready for clinical translation.

Population

Human glioblastoma multiforme (GBM) tissues and cells, and in vivo models of human GBM cells

Intervention

Evaluation of Angiopoietin-4 (Ang-4) effects

Outcome

Tumor angiogenesis, in vivo growth, and Erk1/2 activationsurrogate

Ang-4 promotes glioblastoma progression via angiogenesis and Erk1/2 activation, identifying the Ang-4-Tie-2 axis as a potential therapeutic target.

Brunckhorst et al. (2010) studied this question.

View Full Paper

Ask AI

Bookmark

Ang-4-Tie-2 axis merits further preclinical testing in GBM; hypothesis-generating from animal data and not ready for clinical translation.