January 24, 2005European Journal of Clinical Investigation
Improved early risk stratification and diagnosis of myocardial infarction, using a novel troponin I assay concept
Why the study?
Does a novel investigational cTnI assay improve early diagnosis of myocardial infarction in patients with suspected acute coronary syndrome compared to a reference cTnI assay and myoglobin?
Population
531 patients with suspected acute coronary syndrome
Comparison
Novel investigational cardiac troponin I assay vs Reference cTnI assay and myoglobin
Design
Cohort
Follow-up
24 hours
Authors
Discussion
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Member takes
Implication
May support earlier myocardial injury detection in suspected ACS; leaves open whether the assay improves MI diagnosis pending prospective validation.
Structured PICO
Does a novel investigational cTnI assay improve early diagnosis of myocardial infarction in patients with suspected acute coronary syndrome compared to a reference cTnI assay and myoglobin?
P
Population
531 patients with suspected acute coronary syndrome
I
Intervention
Novel investigational cardiac troponin I (cTnI) assay
C
Comparator
Reference cTnI assay and myoglobin
O
Outcome
Detection of myocardial injury on admission (measured by ROC curve AUC)surrogate
A novel cTnI assay significantly improves the early detection of myocardial infarction upon admission compared to standard cTnI and myoglobin assays.
Cite This Study
Ilva et al. (2005) studied this question.