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September 9, 2015Lupus

Metabolic syndrome is associated with decreased circulating endothelial progenitor cells and increased arterial stiffness in systemic lupus erythematosus

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Why the study?

Is metabolic syndrome associated with increased arterial stiffness and decreased circulating endothelial progenitor cells in female patients with systemic lupus erythematosus?

Population

50 female patients with systemic lupus erythematosus (SLE)

Comparison

Presence of Metabolic syndrome defined according… vs Absence of Metabolic syndrome

Design

Cross-sectional

Authors

RCRaquel CastejónCJCarlos Jimenez-OrtizSRSilvia Rosado

Discussion

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Overview

MetS association with atherosclerosis surrogates in SLE is hypothesis-generating; prospective studies needed before clinical adoption.

Structured PICO

Is metabolic syndrome associated with increased arterial stiffness and decreased circulating endothelial progenitor cells in female patients with systemic lupus erythematosus?

P
Population
50 female patients with systemic lupus erythematosus (SLE)
I
Intervention
Presence of Metabolic syndrome (MetS) defined according to the National Cholesterol Education Program Adult Treatment Panel III
C
Comparator
Absence of Metabolic syndrome
O
Outcome
Inflammatory markers, arterial stiffness (carotid-femoral pulse wave velocity), and circulating endothelial progenitor cells (EPCs)surrogate

Metabolic syndrome in patients with systemic lupus erythematosus is associated with increased arterial stiffness and decreased endothelial progenitor cells, indicating a higher risk of subclinical atherosclerosis.

Cite This Study

Castejón et al. (2015) studied this question.

synapsesocial.com/papers/6a700f5d2163a0a01bc44690https://doi.org/10.1177/0961203315603138
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolic Syndrome Is Associated with Increased Arterial Stiffness and Biomarkers of Subclinical Atherosclerosis in Patients with Systemic Lupus Erythematosus2009 · 84 citations
  2. 2Decreased circulating endothelial progenitor cells as an early risk factor of subclinical atherosclerosis in systemic lupus erythematosus2013 · 44 citations
  3. 3Metabolic syndrome in patients with systemic lupus erythematosus: association with traditional risk factors for coronary heart disease and lupus characteristics2010 · 47 citations
  4. 4Prevalence and Associated Factors of Metabolic Syndrome in Patients With Systemic Lupus Erythematosus: A Cross-Sectional Study2026
  5. 5Association of metabolic syndrome and its components with systemic lupus erythematosus2026