Why the study?
Does intravenous lipopolysaccharide induce different myocardial dysfunction in senescent versus young adult rats?
Population
Senescent (24 month) and young adult (3 month) male Wistar rats
Comparison
Intravenous lipopolysaccharide vs Saline (senescent and young control groups)
Design
Preclinical
Follow-up
12 hours
Authors
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May limit Ca2+-sensitizer utility in aged sepsis; hypothesis-generating for age-specific myocardial responses.
Does intravenous lipopolysaccharide induce different myocardial dysfunction in senescent versus young adult rats?
Low-dose LPS induces severe myocardial dysfunction in senescent rats without altering Ca2+ myofilament responsiveness, suggesting Ca2+-sensitizing agents may be less effective in aged subjects with sepsis.
Rozenberg et al. (2006) studied this question.
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