Why the study?
Does cardiac hypertrophy induced by isoprenaline/caffeine or thyroxine alter baroreflex control of renal sympathetic nerve activity in male Wistar rats?
Population
Male Wistar rats
Comparison
Water containing caffeine and subcutaneous… vs Untreated rats
Design
Preclinical
Follow-up
2 weeks or 7 days
Authors
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Blunted baroreflex control in this rat hypertrophy model may promote sympathetic overactivity; hypothesis-generating and requires human validation.
Does cardiac hypertrophy induced by isoprenaline/caffeine or thyroxine alter baroreflex control of renal sympathetic nerve activity in male Wistar rats?
Cardiac hypertrophy without impaired cardiac function blunts baroreceptor control of renal sympathetic outflow in a rat model.
Flanagan et al. (2008) studied this question.
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