Why the study?
Does L-NAME restore normal renal sympathoinhibitory and excretory responses to volume load in rat models of cardiac hypertrophy?
Population
Normal rats and rat models of cardiac hypertrophy induced by 2 wk of isoprenaline/caffeine or 1 wk thyroxine…
Comparison
L-NAME 10 μg·kg·min for 60 min prior to volume… vs Volume load without L-NAME
Design
Preclinical
Authors
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Hypothesis-generating for NO mediation of blunted volume reflexes in hypertrophy; leaves open translation to human HF therapies.
Does L-NAME restore normal renal sympathoinhibitory and excretory responses to volume load in rat models of cardiac hypertrophy?
Nitric oxide appears to mediate the blunted renal sympathoinhibition and diuresis in response to volume loading in cardiac hypertrophy, as L-NAME restores these reflexes.
Buckley et al. (2011) studied this question.
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