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July 1, 1994Journal of Hypertension

Decreased cardiac baroreflex sensitivity is not due to cardiac hypertrophy in NG-nitro-L-arginine methyl ester-induced hypertension

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Why the study?

Does L-NAME-induced hypertension impair cardiac baroreflex independently of cardiac hypertrophy in adult male Wistar rats?

Population

28 adult male Wistar rats

Comparison

NG-nitro-L-arginine methyl ester orally for 4… vs Tap water

Design

Preclinical

Follow-up

4 weeks

Authors

PLPierre LantelmeMLMing LoJSJ Sassard

Discussion

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Overview

May support baroreflex impairment independent of hypertrophy in L-NAME rats; hypothesis-generating and should not change practice.

Structured PICO

Does L-NAME-induced hypertension impair cardiac baroreflex independently of cardiac hypertrophy in adult male Wistar rats?

P
Population
28 adult male Wistar rats
I
Intervention
NG-nitro-L-arginine methyl ester (L-NAME, 50 mg/kg per 24 h) orally for 4 weeks
C
Comparator
Tap water
O
Outcome
Cardiac baroreflex function (assessed by baroreceptor-heart rate curve via bolus injections of phenylephrine and sodium nitroprusside)surrogate

L-NAME-induced hypertension impairs cardiac baroreflex sensitivity independently of cardiac hypertrophy in a rat model.

Cite This Study

Lantelme et al. (1994) studied this question.

synapsesocial.com/papers/6a832b4088eff2bd7befebfdhttps://doi.org/10.1097/00004872-199407000-00010
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac sympathetic overactivity and decreased baroreflex sensitivity in l -NAME hypertensive rats2001 · 75 citations
  2. 2Sympathetic baroreceptor responses after chronic NG-nitro-L-arginine methyl ester treatment in conscious rats.1994 · 45 citations
  3. 3Cardiac weight in hypertension induced by nitric oxide synthase blockade.1993 · 183 citations
  4. 4Impact of <scp>l</scp>-NAME on the cardiopulmonary reflex in cardiac hypertrophy2011 · 13 citations
  5. 5Discoordinate re-expression of cardiac fetal genes in Nω-nitro-?-arginine methyl ester (?-NAME) hypertension2002 · 18 citations