March 11, 2000Clinical and Experimental Pharmacology and Physiology

Role Of Brain Angiotensin Ii In The Somatosensory Induced Antinatriuresis In The Anaesthetized Rat

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Population

Chloralose-urethane-anaesthetized rats

Comparison

Captopril with or without Angiotensin II… vs Saline i.c.v. followed by capsaicin

Design

Preclinical

Follow-up

30 minutes post-capsaicin administration

Authors

CHChunlong HuangCity University of Macau EJEdward J. JohnsUniversity College Cork

Discussion

Member takes

Implication

Supports brain Ang II in rodent renal sympathetic reflexes; leaves open human translation.

Structured PICO

Population

Chloralose-urethane-anaesthetized rats

Intervention

Captopril (40 microg + 20 microg/h i.c.v.) with or without Angiotensin II (100 ng + 50 ng/h i.c.v.), followed by capsaicin (0.5 mg, s.c.)

Comparator

Saline i.c.v. (2 microL + 1 microL/h) followed by capsaicin (0.5 mg, s.c.)

Outcome

Changes in blood pressure, renal blood flow, glomerular filtration rate, urine flow, and absolute and fractional sodium excretionsurrogate

Brain angiotensin II is necessary for the somatosensory system to induce a reflex increase in renal sympathetic nerve activity causing antinatriuresis and antidiuresis.

Cite This Study

Huang et al. (2000) studied this question.

synapsesocial.com/papers/6a7012f1f44fa9f079dd9970 https://doi.org/10.1046/j.1440-1681.2000.03217.x

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Role Of Brain Angiotensin Ii In The Somatosensory Induced Antinatriuresis In The Anaesthetized Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role Of Brain Angiotensin Ii In The Somatosensory Induced Antinatriuresis In The Anaesthetized Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider