December 1, 1985The Journal of PhysiologyOpen Access

Interaction of the renin‐angiotensin system and the renal nerves in the regulation of rat kidney function.

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Population

Pentobarbitone anaesthetized rats

Comparison

Renal sympathetic nerve stimulation with captopril vs Renal sympathetic nerve stimulation without…

Design

Preclinical

Authors

RHRajash K. HandaIndiana University School of Medicine EJEdward J. JohnsUniversity College Cork

Discussion

Member takes

Implication

Hypothesis-generating in rats; leaves open translation to human renal physiology or therapy.

Structured PICO

Population

Pentobarbitone anaesthetized rats

Intervention

Renal sympathetic nerve stimulation with captopril (0.38 or 0.076 mmol kg-1 h-1)

Comparator

Renal sympathetic nerve stimulation without captopril

Outcome

Renal blood flow, glomerular filtration rate, urine flow, absolute sodium excretion, and fractional sodium excretionsurrogate

This preclinical study demonstrates that the renal nerve-mediated decrease in sodium excretion and regulation of glomerular filtration rate in rats is dependent on angiotensin II.

Cite This Study

Handa et al. (1985) studied this question.

synapsesocial.com/papers/6a7e8b9fc4fd4e6484338d2f https://doi.org/10.1113/jphysiol.1985.sp015903

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Interaction of the renin‐angiotensin system and the renal nerves in the regulation of rat kidney function.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Interaction of the renin‐angiotensin system and the renal nerves in the regulation of rat kidney function.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider