What question did this study set out to answer?

This research aims to evaluate the relationship between heparin's anticoagulant and antithrombotic effects in a rabbit model of venous thrombosis.

February 1, 1977Blood

Relationship between the anticoagulant and antithrombotic effects of heparin in experimental venous thrombosis

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Why the study?

Does continuous infusion of heparin reduce fibrinogen accretion in experimental venous thrombosis in rabbits?

Population

Rabbits with experimental jugular vein thrombi

Comparison

Heparin vs Control

Design

Preclinical

Authors

HCHan‐Mo ChiuNational Taiwan University JHJ Hirsh WYWL YungMcMaster University

Discussion

Member takes

Implication

Findings in rabbits warrant no change in human heparin protocols; leaves open optimal monitoring for antithrombotic efficacy.

Key Points

This research aims to evaluate the relationship between heparin's anticoagulant and antithrombotic effects in a rabbit model of venous thrombosis.
Assessed antithrombotic effects via 125I-fibrinogen accretion on jugular vein thrombi.
Measured anticoagulant effects using protamine sulfate titration and activated partial thromboplastin time (APTT).
Examined bleeding times in relation to APTT and heparin levels.
Continuous infusion of heparin significantly reduced fibrinogen accretion to less than 10% of control at APTT 75-80 sec.
Infusion of cryoprecipitate decreased APTT effects, showing significant inhibition of fibrinogen accretion at similar heparin activity levels but lower APTT (35-50 sec).
Bleeding time increased progressively with higher APTT values and heparin levels in both experimental groups.

Structured PICO

Does continuous infusion of heparin reduce fibrinogen accretion in experimental venous thrombosis in rabbits?

Population

Rabbits with experimental jugular vein thrombi

Intervention

Heparin (continuous infusion vs intermittent injection, with or without cryoprecipitate)

Comparator

Control (no heparin or different administration method)

Outcome

Accretion of 125I-fibrinogen onto jugular vein thrombi (antithrombotic effect)surrogate

Continuous infusion of heparin effectively inhibits fibrinogen accretion in experimental venous thrombosis, with antithrombotic efficacy correlating with heparin activity levels even when APTT is altered by cryoprecipitate.

Cite This Study

Chiu et al. (1977) studied this question.

synapsesocial.com/papers/6a70143a26a7f98052dc97e7 https://doi.org/10.1182/blood.v49.2.171.bloodjournal492171

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Relationship between the anticoagulant and antithrombotic effects of heparin in experimental venous thrombosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Relationship between the anticoagulant and antithrombotic effects of heparin in experimental venous thrombosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider