The study identifies a fourth human tropomyosin gene (hTM alpha) that uses alternative splicing to encode different muscle-type alpha-tropomyosins.
Extends tropomyosin isoform diversity via alternative splicing in fibroblasts; leaves open relevance to cardiovascular muscle biology.
We have isolated a cDNA clone from a human skeletal muscle library which contains the complete protein-coding sequence of a skeletal muscle alpha-tropomyosin. This cDNA sequence defines a fourth human tropomyosin gene, the hTM alpha gene, which is distinct from the hTMnm gene encoding a closely related isoform of skeletal muscle alpha-tropomyosin. In cultured human fibroblasts, the hTM alpha gene encodes both skeletal-muscle- and smooth-muscle-type alpha-tropomyosins by using an alternative mRNA-splicing mechanism.
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MacLeod et al. (1988) studied this question.
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