Why the study?
Does salt with fludrocortisone worsen QT dispersion and left ventricular diastolic function in hypertensive patients with high aldosterone/renin ratios?
Does salt with fludrocortisone worsen QT dispersion and left ventricular diastolic function in hypertensive patients with high aldosterone/renin ratios?
Salt loading with fludrocortisone increases QT dispersion and impairs left ventricular diastolic relaxation independent of blood pressure changes in susceptible hypertensive patients.
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May heighten arrhythmic and diastolic risks with salt loading in high-ARR hypertension; leaves open causal effects and clinical actionability.
Lim et al. (2001) studied this question.
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