Why the study?
Do daily measurements of beta-thromboglobulin (BTG) improve early detection of deep-venous thrombosis in patients with myocardial infarction?
Do daily measurements of beta-thromboglobulin (BTG) improve early detection of deep-venous thrombosis in patients with myocardial infarction?
Serial beta-thromboglobulin measurements are not useful for the early detection of deep-venous thrombosis following myocardial infarction.
Daily BTG measurements should not guide DVT screening post-MI; leaves open the search for effective early-detection biomarkers.
34 patients with myocardial infarction were studied with daily measurements of beta-thromboglobulin (BTG) and 125I fibrinogen scanning in order to detect deep-venous thrombosis (DVT). Serial levels of BTG were unhelpful in the early detection of this condition, which occurred in 7 of the patients studied. 5 of the patients with DVT had received prophylactic heparin and 6 of them were non-smokers. This latter observation is in support of previous studies suggesting an increased incidence of DVT after myocardial infarction in non-smokers as compared to smokers.
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Simmonds et al. (2009) studied this question.
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