Plasma beta-thromboglobulin levels exhibit a distinct temporal pattern in acute myocardial infarction, suggesting early and late phases of platelet activation.
Answers are grounded in this paper and cite their sources.
May signal biphasic platelet activation in acute MI; hypothesis-generating and should not yet change practice.
The plasma beta-thromboglobulin level was studied serially in 14 patients with acute myocardial infarction. In 7 patients the plasma beta-thromboglobulin was initially high. The most severely affected patients had the highest values. Three patients with a mild or moderate clinical course had a normal beta-thromboglobulin level at every stage. The remaining patients had a distinct pattern in the evolution of the plasma beta-thromboglobulin values. The initial phase was followed by a uniform fall during the first days and then by an increase. The highest values were in many cases measured at discharge. Platelet counts showed a similar pattern. Signs of activation of platelets were seen before changes in coagulation and fibrinolysis.
No takes yet. Share an insight, caveat, or question.
Rasi et al. (1980) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: