Myocardial Infarction and Deep-vein Thrombosis
Why the study?
Does anticoagulant therapy reduce the incidence of deep-vein thrombosis in patients with acute myocardial infarction?
Population
52 patients admitted into the coronary intensive care unit, including 31 with confirmed acute myocardial…
Comparison
Anticoagulant therapy vs No anticoagulant therapy
Design
Cohort
Authors
Discussion
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Implication
Anticoagulants were associated with lower DVT rates in AMI; hypothesis-generating and should not yet change practice.
Key Points
- To determine the incidence of deep-vein thrombosis in coronary intensive care patients with acute myocardial infarction and evaluate the impact of anticoagulant therapy.
- Monitored 52 patients admitted to a coronary intensive care unit (N=52), 31 of whom had confirmed acute myocardial infarction.
- Measured the incidence of deep-vein thrombosis using the 125I-fibrinogen uptake test in relation to anticoagulant administration and illness severity.
- In patients with confirmed acute myocardial infarction, deep-vein thrombosis occurred in 38% of untreated patients compared to 5.5% of those receiving anticoagulants.
- Patients categorized as severely ill across all diagnoses demonstrated a deep-vein thrombosis incidence of 68%.
Structured PICO
Does anticoagulant therapy reduce the incidence of deep-vein thrombosis in patients with acute myocardial infarction?
P
Population
52 patients admitted into the coronary intensive care unit, including 31 with confirmed acute myocardial infarction.
I
Intervention
Anticoagulant therapy
C
Comparator
No anticoagulant therapy
O
Outcome
Incidence of deep-vein thrombosis measured with the (125)I-fibrinogen testhard clinical
Anticoagulant therapy appears to substantially reduce the incidence of deep-vein thrombosis in patients admitted with acute myocardial infarction.
Cite This Study
Nicolaides et al. (1971) studied this question.