July 10, 2008BloodOpen Access

High-density lipoprotein cholesterol and venous thromboembolism in the Longitudinal Investigation of Thromboembolism Etiology (LITE)

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Why the study?

Does baseline HDL-c level predict the risk of venous thromboembolism in a general population cohort?

Structured PICO

Does baseline HDL-c level predict the risk of venous thromboembolism in a general population cohort?

Population

19,049 participants of the Longitudinal Investigation of Thromboembolism Etiology (LITE), composed of 14,490 participants of the Atherosclerosis Risk in Communities (ARIC) study and 4,559 participants of the Cardiovascular Health Study (CHS).

Intervention

Baseline high-density lipoprotein cholesterol (HDL-c) levels, subfractions (HDL2 and HDL3), and apolipoprotein A-I (apoA-I)

Comparator

Highest quartile of HDL-c (quartile 4 as reference)

Outcome

Incidence of venous thromboembolism (VTE)hard clinical

Low HDL-c levels are not associated with an increased risk of venous thromboembolism, suggesting HDL-c is not an important VTE risk factor.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Baseline HDL-c levels do not predict VTE risk; leaves open its relevance as a risk factor and should not yet alter practice.

Cite This Study

Chamberlain et al. (2008) studied this question.

synapsesocial.com/papers/6a701e3875498292b7097d18 https://doi.org/10.1182/blood-2008-05-157412

View Full Paper

Ask AI

Bookmark

High-density lipoprotein cholesterol and venous thromboembolism in the Longitudinal Investigation of Thromboembolism Etiology (LITE)

Structured PICO

Discussion

Implication

Cite This Study

High-density lipoprotein cholesterol and venous thromboembolism in the Longitudinal Investigation of Thromboembolism Etiology (LITE)

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider