Why the study?
Severe aortic stenosis in quadricuspid aortic valve is extremely rare, and it is unknown whether TAVR is a safe option due to the low incidence.
Is transcatheter aortic valve replacement planned with cardiac computed tomography safe and feasible in patients with severe aortic stenosis and quadricuspid aortic valve?
Is transcatheter aortic valve replacement planned with cardiac computed tomography safe and feasible in patients with severe aortic stenosis and quadricuspid aortic valve?
TAVR planned with cardiac CT, specifically measuring the annulus at the deepest sinus, appears feasible and safe in the rare population of patients with severe aortic stenosis and quadricuspid aortic valve.
Background: The presence of severe aortic stenosis in quadricuspid aortic valve (QAV) is an extremely rare combination, and it is unknown whether transcatheter aortic valve replacement (TAVR) is a safe option due to the low incidence. Case summary: We present two patients diagnosed with severe aortic stenosis with QAV morphology type 1 (Nakamura classification). All patients presented to our hospital for evaluation because of worsening functional class, dyspnoea, or syncope. During tomographic planning, the aortic annulus was measured at the level of the deepest sinus for the selection of the number of devices. Due to the presence of four cusps, the smallest cusp was excluded, and three sinuses were virtualized for placement of the pigtail catheter during the procedure. Without complications, a 23 mm Edwards SAPIEN 3 was deployed through the femoral artery in both patients. Control aortography showed no valve leakage or regurgitation. Discussion: In patients with QAV and aortic stenosis undergoing TAVR, similar to the tricuspid valve, tomographic planning can be used to ensure the success of the procedure. However, unlike the tricuspid valve, where the selection of the device number is based on the measurements of the aortic annulus at the level of the non-coronary sinus, in these QAV cases, we perform the measurements at the level of the deepest aortic sinus (right coronary sinus).
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Aquino‐Bruno et al. (2024) studied this question.
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