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July 6, 2012Current Heart Failure ReportsOpen Access

New Treatment Options for Late Na Current, Arrhythmias, and Diastolic Dysfunction

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LMLars S. Maier

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Overview

May support ranolazine investigation in AF and diastolic dysfunction; leaves open randomized confirmation before practice change.

Structured PICO

I
Intervention
Ranolazine

This review highlights the potential future clinical indications of ranolazine for arrhythmias (especially atrial fibrillation) and diastolic dysfunction based on its inhibition of the late Na current.

Cite This Study

Lars S. Maier (2012) studied this question.

synapsesocial.com/papers/6a701e9bf44fa9f079dda95ahttps://doi.org/10.1007/s11897-012-0099-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine.1992 · 245 citations
  2. 2Proarrhythmia with Class III Antiarrhythmic Drugs: Definition, Electrophysiologic Mechanisms, Incidence, Predisposing Factors, and Clinical Implications1995 · 158 citations
  3. 3I NaCa contributes to electrical heterogeneity within the canine ventricle2000 · 156 citations
  4. 4Ranolazine Decreases Mechanosensitivity of the Voltage-Gated Sodium Ion Channel Na V 1.52012 · 77 citations
  5. 5An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes2008 · 171 citations