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November 22, 2017VirusesOpen Access

Pressure for Pattern-Specific Intertypic Recombination between Sabin Polioviruses: Evolutionary Implications

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Population

70 recombinants between three serotypes of attenuated Sabin polioviruses and 28 additional recombinants

Comparison

Complete genomic sequencing and location of… vs Previously published data

Design

Preclinical

Authors

ЕКЕ. А. КоротковаRussian Cancer Research Center NN BlokhinMLMajid LaassriUnited States Department of Health and Human ServicesTZTatiana ZagorodnyayaCenter for Biologics Evaluation and Research

Discussion

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Implication

Recombination eliminates low-fitness segments from Sabin polioviruses; leaves open implications for vaccine-derived strain monitoring.

Structured PICO

P
Population
70 recombinants between three serotypes of attenuated Sabin polioviruses and 28 additional recombinants
I
Intervention
Complete genomic sequencing and location of crossover sites
C
Comparator
Previously published data
O
Outcome
Identification of strain-specific segments eliminated by recombination

Identification of weak genomic segments in Sabin polioviruses that are eliminated by recombination could aid in designing more genetically stable oral polio vaccines.

Cite This Study

Короткова et al. (2017) studied this question.

synapsesocial.com/papers/6a70207575498292b70982ebhttps://doi.org/10.3390/v9110353
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Also Consider

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  1. 1New Strains Intended for the Production of Inactivated Polio Vaccine at Low-Containment After Eradication2015 · 36 citations
  2. 2Recombination between Poliovirus and Coxsackie A Viruses of Species C: A Model of Viral Genetic Plasticity and Emergence2011 · 134 citations
  3. 3DNA sequencing with chain-terminating inhibitors1977 · 69,520 citations
  4. 4Mechanisms of genetic variation in polioviruses2010 · 68 citations
  5. 5Common and Diverse Features of Cocirculating Type 2 and 3 Recombinant Vaccine-Derived Polioviruses Isolated From Patients With Poliomyelitis and Healthy Children2012 · 42 citations