Key result
Analysis of poliovirus isolates from South India identified several wild-type/wild-type and wild-type/vaccine recombinants, indicating that recombination is common in natural viral evolution.
Population
Poliovirus isolates, including vaccine-derived strains excreted by poliovirus vaccine vaccinees or…
Design
Preclinical
Authors
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Alerts to recombination risks among circulating polioviruses; leaves open effects on eradication surveillance and vaccine-derived strain monitoring.
Recombination is a common event in the natural evolution of poliovirus strains, including wild-type and vaccine-derived strains.
Dahourou et al. (2002) studied Poliovirus. Restriction fragment length polymorphism (RFLP) and genomic sequencing was evaluated on Identification of recombinant poliovirus genomes. Analysis of poliovirus isolates from South India identified several wild-type/wild-type and wild-type/vaccine recombinants, indicating that recombination is common in natural viral evolution.
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