Why the study?
What are the incidence, excretion kinetics, and genomic features of intertypic recombinant Sabin poliovirus strains in children following primary immunization with OPV?
Population
67 children following primary immunization with trivalent oral poliomyelitis vaccine (OPV)
Design
Cohort
Follow-up
2 to 60 days following vaccination
Authors
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Early recombinant excretion after OPV may inform surveillance; leaves open transmissibility and evolution questions for prospective validation.
What are the incidence, excretion kinetics, and genomic features of intertypic recombinant Sabin poliovirus strains in children following primary immunization with OPV?
Intertypic vaccine-derived recombinant polioviruses are frequently excreted by healthy children following primary OPV vaccination, with specific genomic features shaped by in vivo replication or selection.
Guillot et al. (2001) studied this question.
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