Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 2001Journal of VirologyOpen Access

Genomic Features of Intertypic Recombinant Sabin Poliovirus Strains Excreted by Primary Vaccinees

View Full Paper
Ask AI
Bookmark
Share

Why the study?

What are the incidence, excretion kinetics, and genomic features of intertypic recombinant Sabin poliovirus strains in children following primary immunization with OPV?

Population

67 children following primary immunization with trivalent oral poliomyelitis vaccine (OPV)

Design

Cohort

Follow-up

2 to 60 days following vaccination

Authors

SGSophie GuillotCentre National de la Recherche ScientifiqueNRNatalia I. RomanenkovaSaint Petersburg Pasteur InstituteMCMariana CombiescuInstitutul Cantacuzino

Discussion

Loading...

Member takes

Implication

Early recombinant excretion after OPV may inform surveillance; leaves open transmissibility and evolution questions for prospective validation.

Structured PICO

What are the incidence, excretion kinetics, and genomic features of intertypic recombinant Sabin poliovirus strains in children following primary immunization with OPV?

P
Population
67 children following primary immunization with trivalent oral poliomyelitis vaccine (OPV)
I
Intervention
Trivalent oral poliomyelitis vaccine (OPV)
O
Outcome
Incidence of intertypic vaccine-derived recombinants (VdRec), their excretion kinetics, and genomic featuressurrogate

Intertypic vaccine-derived recombinant polioviruses are frequently excreted by healthy children following primary OPV vaccination, with specific genomic features shaped by in vivo replication or selection.

Cite This Study

Guillot et al. (2001) studied this question.

synapsesocial.com/papers/6a866c0cdc090bdfff1b2fc7https://doi.org/10.1128/jvi.75.13.5740-5751.2001
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tripartite genome organization of a natural type 2 vaccine/nonvaccine recombinant poliovirus1995 · 61 citations
  2. 2Frequent isolation of intertypic poliovirus recombinants with serotype 2 specificity from vaccine‐associated polio cases1991 · 95 citations
  3. 3Antigenic and Molecular Evolution of the Vaccine Strain of Type 3 Poliovirus during the Period of Excretion by a Primary Vaccinee1986 · 205 citations
  4. 4A model for rearrangements in RNA genomes1995 · 70 citations
  5. 5GENETICS OF POLIOVIRUS1993 · 549 citations