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April 1, 1974Journal of General Virology

On the Nature of Poliovirus Genetic Recombinants

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Population

Poliovirus genetic recombinant and parental particles

Comparison

Rate-zonal and isopycnic sedimentation, u.v… vs Parental poliovirus particles

Design

Preclinical

Authors

PCPaul D. CooperAustralian National UniversityASA. Steiner-PryorAustralian National UniversityPSPaul D. ScottiCanadian Mental Health Association

Discussion

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Implication

Does not yet inform clinical poliovirus management; leaves open structural protein roles in inhibitor sensitivity.

Structured PICO

P
Population
Poliovirus genetic recombinant and parental particles
I
Intervention
Rate-zonal and isopycnic sedimentation, u.v. inactivation, and exposure to growth inhibitor 2-(3-chloro-p-tolyl)-5-ethyl-1,3,4-oxadiazole
C
Comparator
Parental poliovirus particles
O
Outcome
Physical characteristics (sedimentation, u.v. inactivation) and genetic segregation

Poliovirus genetic recombinant particles appear to be conventional virus particles, and sensitivity to a specific growth inhibitor depends on a structural protein gene product.

Cite This Study

Cooper et al. (1974) studied this question.

synapsesocial.com/papers/6a6ff37afebe604dd708c47bhttps://doi.org/10.1099/0022-1317-23-1-41
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Proposed Regulator for Poliovirus: The Equestron1973 · 51 citations
  2. 2Effect of Pactamycin on Synthesis of Poliovirus Proteins: a Method for Genetic Mapping1971 · 128 citations
  3. 3Determination of the Gene Sequence of Poliovirus with Pactamycin1971 · 66 citations
  4. 4Inhibition of Poliovirus by Effect of a Methylthiopyrimidine Derivative1970 · 26 citations
  5. 5Evidence for virus-specific noncapsid proteins in poliovirus-infected HeLa cells.1965 · 362 citations