Why the study?
Does fatty liver increase the association of metabolic syndrome with type 2 diabetes and coronary artery calcification in adults without clinical atherosclerosis?
Does fatty liver increase the association of metabolic syndrome with type 2 diabetes and coronary artery calcification in adults without clinical atherosclerosis?
The presence of fatty liver significantly amplifies the association of metabolic syndrome with type 2 diabetes and subclinical atherosclerosis, particularly in women.
May enhance metabolic syndrome risk stratification with fatty liver assessment; hypothesis-generating for diabetes and calcification associations, needing prospective validation.
OBJECTIVE: To analyze the participation of fatty liver (FL) in the association of metabolic syndrome (MS) with type 2 diabetes and coronary artery calcification (CAC). RESEARCH DESIGN AND METHODS: A total of 765 subjects (52% women) aged 30 to 75 years without clinical atherosclerosis were included in this study. MS was defined in accordance with the Adult Treatment Panel III (ATPIII) guidelines, while FL and CAC were identified by computed tomography. RESULTS: There were increasing frequencies of type 2 diabetes and CAC in all three groups: control, MS without FL, and MS plus FL. Multivariable-adjusted logistic regression analyses showed that FL increased the association of MS with type 2 diabetes in both women [odds ratio 10.6 (95% CI 3.4-33.7)] and men [12.1 (4.1-36.1)]. In women, FL also increased the association of MS with CAC [2.34 (1.07-5.12)]. CONCLUSIONS: FL increases the association of MS with type 2 diabetes and subclinical atherosclerosis.
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Juárez-Rojas et al. (2012) studied this question.
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