Down-regulation of KCNA5 gene expression highlights the importance of potassium ion channel reconstruction in the electrical remodeling of atrial fibrillation.
Potassium channel focus in AF warrants targeted study; leaves open clinical translation from Level 5 data.
The down-regulation of KCNA5 gene expression in AF patients is most obvious, and more potassium ion channel expression differences are also significant, so that the potassium ion channel reconstruction may play a dominant or much more important role in AF electrical remodeling.
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Wang et al. (2018) studied this question.
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