January 1, 1989The Journal of PhysiologyOpen Access

Effects of guanosine nucleotides on skinned smooth muscle tissue of the rabbit mesenteric artery.

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Population

Skinned smooth muscle tissues of the rabbit mesenteric artery

Design

Preclinical

Authors

Discussion

May advance research on Ca2+ sensitization mechanisms; leaves open translation from animal models to clinical practice.

Population

Skinned smooth muscle tissues of the rabbit mesenteric artery

Intervention

Guanosine triphosphate (GTP) and guanosine 5'-o-(3-thio)triphosphate (GTP gamma S)

Outcome

Mechanical properties (Ca2+-induced contraction)surrogate

GTP and GTP gamma S enhance Ca2+-induced contraction in skinned smooth muscle tissues by increasing the Ca2+ sensitivity of contractile proteins.

Fujiwara et al. (1989) studied this question.

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