Population
Permeabilized preparations of tonic and phasic smooth muscles that retained coupled receptors and endogenous…
Comparison
Guanosine 5'-O- and norepinephrine vs Baseline conditions, other nucleotides, or…
Design
Preclinical
Authors
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No immediate clinical implications for vascular tone; leaves open translation of MLC20-mediated Ca2+ sensitization from animal models to human therapies.
The study demonstrates that G-protein-coupled agonist-induced Ca2+ sensitization of smooth muscle force development is mediated by increased myosin light chain phosphorylation.
Kitazawa et al. (1991) studied this question.
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