Population
Intact tonic (rabbit pulmonary artery) and phasic (longitudinal layer of guinea pig ileum) smooth muscles
Comparison
Prolonged depolarization with high K+ vs Resting state or changing [K+]o from 109 to 20 mM
Design
Preclinical
Authors
Loading...
Caution against direct extrapolation to human vessels; leaves open crossbridge cooperativity mechanisms in tonic smooth muscle.
The study demonstrates a dissociation between intracellular calcium levels, myosin light chain phosphorylation, and tension in tonic smooth muscle during prolonged depolarization, suggesting cooperativity between phosphorylated and nonphosphorylated crossbridges.
Himpens et al. (1988) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: