May 1, 1998Journal of Cardiovascular Pharmacology

Autonomic Effects of Nicotine Patch Administration in Habitual Cigarette Smokers: A Double-Blind, Placebo-Controlled Study Using Spectral Analysis of RR Interval and Systolic Arterial Pressure Variabilities

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Why the study?

Does transdermal nicotine alter autonomic regulation (RR interval and SAP variability) compared to placebo or cigarette smoking in heavy smokers?

Population

27 heavy smokers, mean age 43 +/- 2 years

Comparison

Transdermal nicotine and cigarette smoking vs Placebo

Design

RCT, double-blind

Authors

DLDaniela LuciniGeneral / Preventive / Lipids FBFederico BertocchiUniversity of Minnesota AMAlberto MallianiElectrophysiology

Discussion

Member takes

Implication

Supports nicotine patch use in smoking cessation without autonomic concerns; confirms lack of significant sympathomimetic effects versus placebo.

Structured PICO

Does transdermal nicotine alter autonomic regulation (RR interval and SAP variability) compared to placebo or cigarette smoking in heavy smokers?

Population

27 heavy smokers, mean age 43 +/- 2 years

Intervention

Transdermal nicotine (nicotine patch) and cigarette smoking (evaluated in a crossover design)

Comparator

Placebo

Outcome

Autonomic effects assessed by spectral analysis of RR interval and systolic arterial pressure (SAP) beat-by-beat variabilities (including LF component, LF/HF ratio, and index alpha)surrogate

Nicotine patches do not cause significant sympathomimetic autonomic disturbances compared to placebo, supporting their cardiovascular safety in smoking cessation.

Cite This Study

Lucini et al. (1998) studied this question.

synapsesocial.com/papers/6a702b436c240de38cdbb3b5 https://doi.org/10.1097/00005344-199805000-00010

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Implication

Supports nicotine patch use in smoking cessation without autonomic concerns; confirms lack of significant sympathomimetic effects versus placebo.

Autonomic Effects of Nicotine Patch Administration in Habitual Cigarette Smokers: A Double-Blind, Placebo-Controlled Study Using Spectral Analysis of RR Interval and Systolic Arterial Pressure Variabilities

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Autonomic Effects of Nicotine Patch Administration in Habitual Cigarette Smokers: A Double-Blind, Placebo-Controlled Study Using Spectral Analysis of RR Interval and Systolic Arterial Pressure Variabilities

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider