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September 1, 1972Journal of Biomedical Materials Research

Lipid absorption by silicone heart valve poppets—in‐vivo and in‐vitro results

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Population

Silicone rubber heart valve poppets (in-vivo and in-vitro models)

Design

Preclinical

Authors

RCRaleigh CarmenPall Corporation (United States)SMS.C. MuthaAnalytical Services

Discussion

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Implication

Lipid absorption may cause silicone poppet variance; hypothesis-generating for prosthetic valve failure mechanisms, requiring human studies.

Structured PICO

P
Population
Silicone rubber heart valve poppets (in-vivo and in-vitro models)
I
Intervention
Exposure to blood stream and lipids
O
Outcome
Lipid absorption by silicone rubber poppetssurrogate

Silicone heart valve poppets can absorb lipids from the bloodstream, which in a small percentage of cases leads to material variance due to oxidation products of polyunsaturated fatty acids.

Cite This Study

Carmen et al. (1972) studied this question.

synapsesocial.com/papers/6a702bb331a3df824328723bhttps://doi.org/10.1002/jbm.820060504
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prediction of Lipid Uptake by Prosthetic Heart Valve Poppets from Solubility Parameters1973 · 24 citations
  2. 2Lipids in Silicone Rubber Valve Prostheses After Human Implantation1971 · 33 citations
  3. 3In vivo degradation of silicone rubber poppets in prosthetic heart valves1976 · 21 citations
  4. 4Macromolecular transport in heart valves. III. Experiment and theory for the size distribution of extracellular liposomes in hyperlipidemic rabbits2007 · 13 citations
  5. 5The fate and fibrogenic potential of subintimal implants of crystalline lipid in the canine aorta. Quantitative histological and autoradiographic studies.1978 · 12 citations