Population
3 nonvariant silicone rubber poppets recovered from aortic prosthetic heart valves implanted for 4 days, 52…
Comparison
In vivo implantation in aortic prosthetic heart… vs Unused silicone rubber poppets
Design
Preclinical
Follow-up
4 days, 52 days, and 8 years
Authors
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Raises caution on long-term silicone poppet durability in valves; animal data leaves open human translation.
Silicone rubber poppets in prosthetic heart valves undergo in vivo degradation over time, with surface degradation occurring faster than core degradation.
Cuddihy et al. (1976) studied this question.
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