Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 2, 2003BloodOpen Access

Initial accumulation of platelets during arterial thrombus formation in vivo is inhibited by elevation of basal cAMP levels

View Full Paper
Ask AI
Bookmark
Share

Population

in vivo model of arterial thrombosis

Design

Preclinical

Authors

DSDerek SimBeth Israel Deaconess Medical CenterGMGlenn Merrill‐SkoloffBeth Israel Deaconess Medical CenterBFBarbara C. FurieUniversity of North Carolina at Chapel Hill

Discussion

Loading...

Member takes

Overview

Should not alter antithrombotic practice; hypothesis-generating for PDE3A inhibition in arterial thrombosis.

Structured PICO

P
Population
in vivo model of arterial thrombosis
I
Intervention
Phosphodiesterase 3A (PDE3A) inhibitors (cilostazol and a newly discovered inhibitor)
O
Outcome
Platelet accumulation at the site of vascular injury (including initial rate of accumulation, attachment, and detachment)surrogate

Elevation of basal cAMP levels via PDE3A inhibition reduces initial platelet accumulation and alters attachment/detachment kinetics during arterial thrombus formation in vivo.

Cite This Study

Sim et al. (2003) studied this question.

synapsesocial.com/papers/6a702e27ac440176ef28d383https://doi.org/10.1182/blood-2003-04-1133
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prostacyclin and Sodium Nitroprusside Inhibit the Activity of the Platelet Inositol 1,4,5-Trisphosphate Receptor and Promote Its Phosphorylation1996 · 148 citations
  2. 2Antiplatelet and Antithrombotic Effects of a Novel Selective Phosphodiesterase 3 Inhibitor, NSP-513, in Mice and Rats2000 · 14 citations
  3. 3Targeted Gene Disruption Demonstrates That P-Selectin Glycoprotein Ligand 1 (Psgl-1) Is Required for P-Selectin–Mediated but Not E-Selectin–Mediated Neutrophil Rolling and Migration1999 · 320 citations
  4. 4A Randomized Comparison of Antiplatelet and Anticoagulant Therapy after the Placement of Coronary-Artery Stents1996 · 2,038 citations
  5. 5Distinct localization and function of1,4,5IP3 receptor subtypes and the1,3,4,5IP4 receptor GAP1IP4BP in highly purified human platelet membranes2000 · 63 citations