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October 30, 2008Ultrasound in Obstetrics and GynecologyOpen Access

Validation of the fetal myocardial performance index in the second and third trimesters of gestation

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Why the study?

Is the fetal myocardial performance index a valid and reproducible measure of cardiac function compared to conventional methods in normal and volume-overloaded fetuses?

Population

117 healthy fetuses and 14 fetuses suspected of cardiac failure because of twin-twin transfusion syndrome.

Comparison

Measurement of the fetal myocardial performance… vs Conventional methods of fetal cardiac function…

Design

Cohort

Authors

TMTim Van MieghemMount Sinai HospitalLGLéonardo GucciardoMathys (Netherlands)PLPaul LewiUniversity of Antwerp

Discussion

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Implication

MPI may offer a reproducible fetal cardiac marker where EF is limited; leaves open prospective outcome validation before clinical use.

Structured PICO

Is the fetal myocardial performance index a valid and reproducible measure of cardiac function compared to conventional methods in normal and volume-overloaded fetuses?

P
Population
117 healthy fetuses (gestational age range, 20-36 weeks) and 14 fetuses suspected of cardiac failure because of twin-twin transfusion syndrome (TTTS).
I
Intervention
Measurement of the fetal myocardial performance index (MPI)
C
Comparator
Conventional methods of fetal cardiac function assessment: ejection fraction (EF) and E/A index
O
Outcome
Correlation between MPI, EF, and E/A index, and interobserver/intraobserver variabilitysurrogate

The fetal myocardial performance index is a highly reproducible and easily acquired indicator of systolic left ventricular function that correlates strongly with ejection fraction.

Cite This Study

Mieghem et al. (2008) studied this question.

synapsesocial.com/papers/6a702ea4ac440176ef28d3e5https://doi.org/10.1002/uog.6238
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quantitative Assessment of Fetal Ventricular Function: Establishing Normal Values of the Myocardial Performance Index in the Fetus2001 · 125 citations
  2. 2Gestational‐age‐adjusted reference values for the modified myocardial performance index for evaluation of fetal left cardiac function2007 · 159 citations
  3. 3Serial evaluation for myocardial performance in fetuses and neonates using a new Doppler index1999 · 227 citations
  4. 4Fetal cardiac function assessed by Doppler myocardial performance index (Tei Index)2003 · 211 citations
  5. 5Utility of a Doppler-derived index combining systolic and diastolic performance (Tei index) for detecting hypoxic cardiac damage in newborns2005 · 28 citations