Myocardial metabolism in relation to electrocardiographic changes and cardiac function during graded hypoxia in the fetal lamb

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Population

21 fetal lambs, acutely exteriorized

Design

Preclinical

Authors

Discussion

May link fetal ECG changes to myocardial energy depletion; leaves open translation to human monitoring.

Population

21 fetal lambs, acutely exteriorized

Intervention

graded hypoxia

Outcome

Correlation between ST-T period ECG changes and depletion of myocardial glycogen and ATPsurrogate

In a fetal lamb model, hypoxic ECG changes in the ST-T period correlate significantly with the depletion of myocardial glycogen and ATP stores.

Hökegård et al. (1981) studied this question.

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