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June 1, 1999Annals of the New York Academy of Sciences

Metabolic Changes in the Normal and Hypoxic Neonatal Myocardium

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Population

Neonatal piglet model

Comparison

Chronic hypoxia vs Non-hypoxic conditions

Design

Preclinical

Authors

SASalah Abdel‐aleemCity College of New YorkJLJames D. St. LouisCardiac SurgeryGHG. Chad HughesDuke University

Discussion

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Implication

Hypothesis-generating for neonatal cardioprotection strategies; leaves open translation to human congenital heart disease.

Structured PICO

P
Population
Neonatal piglet model
I
Intervention
Chronic hypoxia
C
Comparator
Non-hypoxic conditions
O
Outcome
Cardiac myocyte substrate utilization and ischemic tolerancesurrogate

Chronic hypoxia in neonatal hearts induces metabolic adaptations, such as increased anaerobic glycolysis, that confer greater tolerance to subsequent ischemia.

Cite This Study

Abdel‐aleem et al. (1999) studied this question.

synapsesocial.com/papers/6a776af17d04941475ae4b2dhttps://doi.org/10.1111/j.1749-6632.1999.tb09240.x
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