Key result
Lamb myocardial metabolism does not immediately switch from carbohydrates to fatty acids after birth.
Why the study?
No information is available on perinatal changes in myocardial metabolism in vivo.
Population
Fetal, newborn (1-4 days), and juvenile (7 wk) lambs
Comparison
Myocardial supply and flux of fatty acids, carbohydrates, and ketone bodies at different ages
Design
In vivo measurement using chronically instrumented lambs
Authors
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Challenges immediate postnatal metabolic switch assumption; leaves open substrate utilization timeline in human neonates.
Bartelds et al. (1998) studied Perinatal changes in myocardial metabolism. Perinatal development (fetal, newborn, juvenile stages) vs. Fetal lambs was evaluated on Myocardial supply and flux of fatty acids, carbohydrates, and ketone bodies. In vivo myocardial metabolism in lambs does not switch immediately after birth from carbohydrates (accounting for 89% and 69% of oxygen consumption in fetal and newborn lambs) to fatty acids.
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